Scientists Identify First Sign Of Alzheimer's Disease

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Article by Dana Dovey

Memory loss and cognitive decline are commonly thought to be the earliest signs of the neurodegenerative disorder Alzheimer's, but a new study has found declines in glucose levels in the brain come even sooner — before the first symptoms appear. Even better? The same team also believes they have figured out a way to stop these levels from falling in the first place, a finding that could potentially prevent Alzheimer's.

Although doctors have long noted the association between declining glucose levels in the brain and the onset of Alzheimer’s disease, for the first time ever, a study now published online in the journal Translational Psychiatry has proved that these declining energy levels are a direct trigger for the cognitive impairments traditionally associated with the disease. According to a recent statement on the study, this may explain why diabetes, a condition in which glucose cannot enter the cells, is a known risk factor for dementia. According to the study, a protein known as p38 may be able to prevent this deprivation from occurring.

"The findings are very exciting," explained lead researcher Dr. Domenico Praticò in a statement. "There is now a lot of evidence to suggest that p38 is involved in the development of Alzheimer's disease."

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